DNA Methylation Market by Product (Consumables, Software, Instruments); by Technology (Polymerase Chain Reaction (PCR), Microarray, Others); by Application (Oncology Research, Clinical Applications, Translational Research, Non-Oncology Research); by Region (North America, Europe, Asia-pacific, Latin America, Middle East Africa): Global Forecasts 2021 To 2027

The Global DNA Methylation Market size was valued at USD 1.5 Bn in 2020 and is expected to reach USD 4.5 Bn by 2027, with a growing CAGR of 17% during the forecast period

DNA methylation is defined as process of adding or removing methyl group (-CH3) into DNA strand. This addition of methyl group helps to alter or change the activity of DNA segment without changing the sequence. Presence of methyl group on gene promoter edge will repress gene transcription. DNA methylation process is used during gene editing, regulating tissue-specific gene expression and X-chromosome inactivation.

DNA Methylation Market Size

The driving factors for global DNA methylation market include growing prevalence of cancer diseases, decreasing treatment cost and increase in product approvals. Moreover, increase in application of DNA methylation in early-stage biomarkers in cancer detection fuels the growth of global DNA methylation market. Strong government support in terms of funding & grants for research activities and rise in number of key players boost the growth of DNA methylation industry.

Further, emerging innovative therapies & products and surge for the development of various testing options for cancer amongst companies drives the growth of global DNA methylation market.

DNA Methylation Market Segmentation:

By Product

  • Consumables
  • Software
  • Instruments

By Technology

  • Polymerase Chain Reaction (PCR)
  • Microarray
  • Others

By Application

  • Oncology Research
  • Clinical Applications
  • Translational Research
  • Non-Oncology Research

By Region

  • North America
  • Europe
  • Asia-Pacific
  • Latin America
  • Middle East & Africa

Based on product, consumables dominated the growth of DNA methylation market in 2020 due to rise in its diagnostics usage

Based on product, DNA methylation market is segmented into consumables, software and instruments. Consumables accounted for highest market share due to increase in usage of instant test and rise in demand for regular wear out use. Consumables are widely used in diagnosis process, DNA sequencing procedures. Increase in demand for high throughput results and fast result rate drive the growth of this segment in DNA methylation market.

Based on technology, polymerase chain reaction held maximum market share in 2020 and expected to increase more due to increase in its usage during DNA sequencing

Based on technology, DNA methylation market is segmented into Polymerase Chain Reaction (PCR) and microarray. Polymerase chain reaction segment accounted for the highest market share in 2020 due to increase in its application in diagnostics and DNA sequencing process. Increase in demand for PCR technology in diagnostics and genomics triggered the growth of DNA methylation. During covid-19, PCR technology gained immense importance as diagnostic procedure across the world.

Based on application, oncology segment accounted for the largest market share due to rise in incidence of cancer patients

Based on application, DNA methylation market segmented into oncology research, clinical applications, translational research and non-oncology research. Oncology segment accounted for the highest market share owing to increase in various types of cancer such as breast cancer, blood cancer, lung cancer. Moreover, rise in government funding for gene-based research, rise in healthcare expenditure and growing illness among geriatric population drives the growth of this segment in DNA methylation market.

Based on geographical region, North America held the largest share in DNA methylation market in 2020 and expected to increase more during forecast period due to rapid development of healthcare infrastructure

Based on region, North America accounted for the highest market share in 2020 due to presence of majority of players in this region. Moreover, immense network of manufacturing and R&D centers, rise in product launch & approvals and increase in demand for protein expression system thrives the growth of DNA methylation market in this region. Increase in manufacturing of vaccines, antibodies, insulin and hormones in this region, propels the growth of DNA methylation industry. In addition to this, United States is considered to be world’s largest spender on healthcare facilities and research across the globe. Aforementioned factors contribute to the expansion of DNA methylation market during forecast period.

Company Profiles and Competitive Intelligence

The key players operating in the DNA methylation market are:

  • Abcam plc
  • Active Motif, Inc.
  • Agilent Technologies, Inc.
  • Diagenode Diagnostics S.A.
  • EpiGentek Group Inc.
  • Exact Sciences Corporation
  • Hoffmann-La Roche Ltd.
  • Illumina, Inc.
  • Merck
  • Pacific Biosciences of California, Inc.
  • PerkinElmer, Inc.
  • QIAGEN N.V.*
  • Thermo Fisher Scientific Inc.
  • Zymo Research Corporation
  • New England Biolabs
  • MDx Health S.A.
  • Exact Science Corporation
  • Takara Bio Group
  • AnchorDX
  • Epigenomics AG
  • Binano Genomics
  • Genetix Biotech Asia

The report also provides an in-depth analysis of DNA methylation market dynamics such as drivers, restraints, opportunities and challenges


  • Rise in demand for protein-based therapies
  • Increase in R&D facilities
  • Increase in government spending on research and healthcare
  • Increase in prevalence of cancer diseases


  • Stringent government policies for product approvals
  • High instrument cost


  • Growing trend in methylation for precision medicine
  • Technological advancements in methylation sequencing


  • Lack of skilled professionals
  • Lack of high-complexity centres 

COVID-19 Impact on the DNA Methylation Market Analysis

Covid-19 has highly affected the industries in terms of growth, economy, health and mental wellbeing of every individual. In this challenging situation, every industry is trying to give best services in terms of quality and safety. Covid –19 outbreak has badly affected the growth of DNA methylation industry. Government restrictions on nation has affected the movement of personnel or products across the country. Manufacturing process, supply chain, import & export of goods/services declined due to lockdown.

Moreover, patients related to the genetic problems or long-lasting diseases patients were kept on hold and priority was given to the virus infected population. However, researchers have developed the application and usage of PCR and other genetic testing procedures in analysing the nature of coronavirus and related treatment. PCR has gained immense importance during pandemic due to its application in virus diagnosis. This fuelled the growth and rose the demand for DNA methylation market across the globe.

The report also provides an in-depth analysis of key trends in DNA methylation market

  • During covid-19, sudden decrease in number of patients and disposable income level on healthcare, affected the growth of DNA methylation market across the globe. 
  • Increase in government spending on clinical trials, development in innovative and non-invasive techniques and rising demand for genetic therapies drives the growth of DNA methylation market.

The report also provides an in-depth analysis of recent news developments and investments

  • In April 2019, New England Biolabs launched new product namely, ‘NEBNext Enzymatic Methyl-seq (EM-seq™)’, as an alternative for bisulfite sequencing for methylation analysis
  • In January 2018, Thermo Fisher Scientific signed official agreement with Illumina to sell AmpliSeq technology to researchers for conducting scientific studies

The unique insights provided by this report also includes the following:

  • In-depth Value Chain Analysis
  • Opportunity Mapping
  • Sector Snapshot
  • Key Players Positioning Matrix
  • Regulatory Scenario
  • Strategies Adopted-Benchmarking Heat Map
  • Market Trends
  • Covid-19 Impact Analysis
  • Product Comparison
  • Pre & Post COVID 19 Impacts on DNA Methylation Market
  • Competitive Landscape

Frequently Asked Questions (FAQs)

The global DNA methylation market was valued at USD 1.5 Bn in 2020 and is anticipated to reach USD 4.5 Bn by 2027.

The global DNA methylation market is estimated to grow at a compound annual growth rate (CAGR) of 17% during forecast period.

In the base year 2020, North America accounted for about 75% share in the DNA methylation market.

High treatment cost and lack of trained professional restraint the growth of global DNA methylation market.

As per expert opinions, increase in demand for gene-based therapy and rise in government spending on healthcare & research facilities will the drive the growth of global DNA methylation market.

Few key players include, but not limit up to: Hoffmann-La Roche Ltd., Abcam plc,Active Motif, Inc., Agilent Technologies, Inc., Merck, Diagenode Diagnostics S.A., EpiGentek Group Inc., Exact Sciences Corporation, Illumina, Inc., Pacific Biosciences of California, Inc., PerkinElmer, Inc., QIAGEN N.V. and Thermo Fisher Scientific Inc.

Related Reports

Need specific market information ?

Ask for free product review call with the author

Share your specific research requirements for a customized report

Request for due diligence and consumer centric studies

Request for study updates, segment specific and country level reports

  1.  Introduction
    1. Product Outline
    2. What is DNA Methylation Market?
    3. Analysis of DNA Methylation Market
    4. Covid -19 Impact
    5. Market Dynamics
      1. Drivers
      2. Restraints
      3. Opportunities
      4. Threats
    6. Technology Overview
  2. Regulatory Landscape for DNA Methylation Market
    1. Regulations and Standards
  3. DNA Methylation Market by Product
    1. Consumables
    2. Software
    3. Instruments
  4. DNA Methylation Market by Technology
    1. Polymerase Chain Reaction (PCR)
    2. Microarray
    3. Others
  5. DNA Methylation Market by Application
    1. Oncology Research
    2. Clinical Applications
    3. Translational Research
    4. Non-Oncology Research
  6. Regional Analysis
    1. North America
      1. US
      2. Canada
    2. Europe
      1. Germany
      2. UK
      3. France 
      4. Spain
      5. Italy
      6. Rest Of Europe
    3. Asia Pacific
      1. China
      2. India
      3. Japan
      4. Australia
      5. Rest Of Asia Pacific
    4. Latin America
    5. Middle East Africa
  7. Key Strategic Insights
  8. Market Analysis
    1. New Applications
    2. Emerging Technologies
    3. Opportunity Mapping
    4. Consumer Preferences  
  9. Key Market Trends / Recent Developments
  10. Competitive Scenario
    1. Mergers and Acquisitions
    2. Investments
    3. Joint Ventures
    4. New Product Launches
    5. Ranking of Key Players
  11. Key global players
    1. Abcam plc
    2. Active Motif, Inc.
    3. Agilent Technologies, Inc.
    4. Diagenode Diagnostics S.A.
    5. EpiGentek Group Inc.
    6. Exact Sciences Corporation
    7. Hoffmann-La Roche Ltd.
    8. Illumina, Inc.
    9. Merck
    10. Pacific Biosciences of California, Inc.
    11. PerkinElmer, Inc.
    12. QIAGEN N.V.*
    13. Thermo Fisher Scientific Inc.
    14. Zymo Research Corporation
    15. New England Biolabs

Choose License

License Type
Ask for Customization

Why Choose AllTheResearch?

  • Monthly market updates for 6 months
  • Online access of reports
  • Options to buy sections of report
  • Critically analysed research on Quadrant Positioning of your company.
  • Syndicated report along with a supplementary report with objective-based study
  • Get profiled in the reports.Expanding your visibility across our network of readers and viewers
  • We provide local market data in local language on request
  • A complementary co-branded white paper
  • Flat consulting fee based exclusive studies. Consult at the price of syndicate
  • Access to expert team for free transaction advisory service.
Speak to Analyst

Quick Inquiry

Follow Us

Choose License

License Type
Ask for Customization